Aurora Kinase/Cdk Inhibitor Aurora Kinase/Cdk inhibitor (JNJ-7706621) is a cell-permeable triazolylsulfonamido compound that acts as a reversible, ATP-competitive kinase inhibitor selective towards ARKs and Cdk's.

Aurora Kinase/Cdk Inhibitor  (CAS 443797-96-4)

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Synonym: JNJ-7706621, 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide
Application: (JNJ-7706621) a cell-permeable, reversible, ATP-competitive kinase inhibitor
CAS Number: 443797-96-4
Purity: ≥97%
Molecular Weight: 435.4
Molecular Formula: C15H12F2N6O3S CH3CN
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Aurora Kinase/Cdk Inhibitor sc-203829 5 mg $440.00

Aurora Kinase/Cdk inhibitor (JNJ-7706621) is a cell-permeable triazolylsulfonamido compound that acts as a reversible, ATP-competitive kinase inhibitor with selectivity towards ARKs (IC50 = 11 and 15 nM for ARK-1 (Aurora-A) and ARK-2 (Aurora-B), respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdc2 (Cdk1)/B, Cdk2/A, and Cdk2/E, respectively). Aurora Kinase/Cdk Inhibitor displays antitumor properties (IC50 in the range of 112-514 nM against various human cancer cell lines).


References

1. Emanuel, S. et al. 2005. Cancer Res. 65(19): 9038-9046. PMID: 16204078
2. Lin, R. et al. 2005. J. Med. Chem. 48(13): 4208-4211. PMID: 15974571
3. Seamon, J.A. et al. 2006. Mol. Cancer Ther. 5(10): 2459-2467. PMID: 17041089

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at 4° C
IC50 :
Aurora-A: IC50 = 11 nM; Aurora-B: IC50 = 15 nM; Cdk1/B: IC50 = 9 nM; Cdk2/A: IC50 = 4 nM; Cdk2/E: IC50 = 3 nM; cancer cell lines: IC50 = 112 - 514 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760303
SMILES :
CC#N.Nc1nc(Nc2ccc(cc2)S(=O)(=O)N)nn1C(=O)c1c(F)cccc1F

Download SDS (MSDS)

Certificate of Analysis

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