Bakuchiol Bakuchiol is an inhibitor of PTB1B (protein tyrosine phosphatase 1B) and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol shows antimicrobial and cytotoxic activity.

Bakuchiol  (CAS 10309-37-2)

Bakuchiol is rated 5.0 out of 5 by 1.
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| See 1 Citations
Synonym: 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
Application: A PTP1B and DNA polymerase inhibitor
CAS Number: 10309-37-2
Purity: ≥97%
Molecular Weight: 256.4
Molecular Formula: C18H24O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Bakuchiol sc-202075 1 mg $40.00

Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B). It also acts as an inhibitor of mitochondrial lipid peroxidation and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol is also a DNA polymerase inhibitor which shows antimicrobial and cytotoxic activity.


References

1. Pae, H.O. et al. 2001. Int. Immunopharmacol. 1(9-10): 1849-1855. PMID: 11562076
2. Backhouse, C.N. et al. 2001. J Ethnopharmacol. 78(1): 27-31. PMID: 11585684
3. Haraguchi, H. et al. 2002. Phytother Res. 16(6): 539-544. PMID: 12237811
4. Adhikari, S. et al. 2003. Chem. Res. Toxicol. 16(9): 1062-1069. PMID: 12971793
5. Bapat, K. et al. 2005. Appl Radiat Isot. 62(3): 389-393. PMID: 15607914
6. Kim, Y.C. et al. 2005. Planta Med. 71(1): 87-89. PMID: 15678382
7. Park, E.J. et al. 2005. Planta Med. 71(6): 508-513. PMID: 15971120
8. Park, E.J. et al. 2007. Eur. J. Pharmacol. 559(2-3): 115-123. PMID: 17292878

Appearance :
Oil
Physical State :
Liquid
Derived From :
Psoralea corylifolia
Solubility :
Soluble in DMSO, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
106.00° C (Predicted)
Boiling Point :
391.38° C (Predicted)
Density :
0.96 g/mL (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
HeLa: IC50 = 11 µM (human); AGS: IC50 = 15.3 µM (human); T47D: IC50 = 28.9 µM (human)
pK Values :
pKa: 10.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5468522
MDL Number :
MFCD01707441
SMILES :
CC(=CCC[C@@](C)(C=C)/C=C/C1=CC=C(C=C1)O)C

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Certificate of Analysis

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Citations 1 to 1 of 1 total

PMID: # 25860621
Choi, JM. et al. 2015. Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes. Chem. Res. Toxicol.. 28: 872-85.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Park et al Park et al. (PubMed ID 17292878) found that bakuchiol reduced activated hepatic stellate cells of rats recovering from liver injury by inducing apoptosis via activation of caspase 3. -SCBT Publication Review
Date published: 2015-02-23
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