Cantharidic Acid Cantharidic acid is an analog of cantharidin (CA) that is a potent and selective inhibitor of protein phosphatase (PP2A) and PP1(protein phosphatase 1). Does not inhibit PP2B or PP2C.

Cantharidic Acid  (CAS 28874-45-5)

Cantharidic Acid is rated 5.0 out of 5 by 1.
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Synonym: 2,3-Dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Application: A potent and selective inhibitor of PP2A and PP1
CAS Number: 28874-45-5
Purity: 98%
Molecular Weight: 214.21
Molecular Formula: C10H14O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Cantharidic Acid sc-201323 10 mg $60.00
Cantharidic Acid sc-201323A 50 mg $240.00

Cantharidic acid, an analog of cantharidin (CA), is a potent and selective inhibitor of PP2 (protein phosphatase (PP2A) and PP1 (protein phosphatase 1). PP2A regulates phosphorylation-dephosphorylation events and is found in plants and mammalian tissues. Studies show that it can cause biochemical changes in the mouse liver. Both okadaic acid (sc-3513), also a PP2A inhibitor, and cantharidic acid have been demonstrated to elevate levels of microtubule-bound phospho-53 in the breast cancer cell line, MCF7. Cantharidic acid does not inhibit PP2B or PP2C.


References

1. Graziano, M.J. and Casida, J.E. 1987. Toxicol. Lett. 37: 143-148. PMID: 2955551
2. Li, Y.M. and Casida, J.E. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 11867-11870. PMID: 1334551
3. Li, Y.M., et al. 1993. Biochem. Pharmacol. 46: 1435-1443. PMID: 8240393
4. Béghin, A., et al. 2008. Cell Cycle. 7: 3074-3082. PMID: 18818514

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (10 mg/ml warm). Partly miscible in water.
Storage :
Store at room temperature
Melting Point :
216-218° C
Boiling Point :
407.76° C at 760 mmHg
Density :
1.36 g/cm3
Refractive Index :
n20D 1.53
IC50 :
PP2A: IC50 = 53 nM; PP1: IC50 = 0.56 µM
pK Values :
pKa: 3.70
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
121475
MDL Number :
MFCD00047137
SMILES :
C[C@]1([C@H]2CC[C@@H]([C@]1(C)C(=O)O)O2)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Beghin et al Beghin et al. (PubMed ID 18818514) showed that cantharidic acid-mediated inhibition of PPA2 increased mirotubule-bound phospho-p53 and reduced sensitivity to chemotherapy in breast cancer cells. -SCBT Publication Review
Date published: 2015-07-04
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