Cantharidin Cantharidin is a small molecule herbicide and potent inhibitor of PP2A (IC50=40 nM).

Cantharidin  (CAS 56-25-7)

Cantharidin is rated 5.0 out of 5 by 1.
  • 2016-09-25T11:58CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201321, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 64ms
  • REVIEWS, PRODUCT
| See 4 Citations
Synonym: Cantharone
Application: A toxic herbicidal potent inhibitor of PP2A phosphatase activity
CAS Number: 56-25-7
Purity: ≥98%
Molecular Weight: 196.20
Molecular Formula: C10H12O4
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Cantharidin sc-201321 25 mg $57.00
Cantharidin sc-201321A 100 mg $178.00

Cantharidin is a potent small molecule inhibitor of PP2A (protein phosphatase 2A), used as an herbicide and a known toxin to animals. Cantharidin shows strong inhibition of PP2A (IC50=40 nM) compared to the analog Endothall (sc-201325), with Cantharidin displaying near complete inhibition of phosphatase activity.


References

1. Li, Y.M. and Casida, J.E. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 11867-11870. PMID: 1334551
2. Li, Y.M., et al. 1993. Biochem. Pharmacol. 46: 1435-1443. PMID: 8240393

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).
Storage :
Store at room temperature
Melting Point :
215-217° C
Boiling Point :
326.87° C at 760 mmHg
Density :
1.36 g/cm3
Refractive Index :
n20D 1.55
IC50 :
protein phosphatase 2A: IC50 = 40 nM; protein phosphatase 1: IC50 = 473 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RN8575000
Transport :
UN 2811, Class 6.1, Packing group I
PubChem CID :
5944
Merck Index :
14: 1752
MDL Number :
MFCD00134968
EC Number :
200-263-3
SMILES :
CC12C3CCC(C1(C(=O)OC2=O)C)O3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

Cantharidin Product Citations

See how others have used Cantharidin. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 14993658
Macdonald, A. et al. 2004. The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity. J. Gen. Virol.. 85: 721-729.

PMID: # 12676746
Luo, G. et al. 2003. IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B. Am. J. Physiol. Regul. Integr. Comp. Physiol.. 284: R1249-R1254.

PMID: # 10409765
Guttridge, D. et al. 1999. NF-(kappa)B controls cell growth and differentiation through transcriptional regulation of cylin d1 Mol. Cell. Biol. 19: 5785-5799.

PMID: # 9353326
Gabrielli, BG. et al. 1997. Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2. J. Biol. Chem.. 272: 28607-28614.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 78ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Luo Luo, et. al. (PubMed ID 12676746) utilized cantharidin in their cytosolic and nuclear lysis buffers. -SCBT Publication Review
Date published: 2015-03-31
  • 2016-09-25T11:58CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201321, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2016 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.