CAY 10566 A potent and selective inhibitor of SCD1; inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells.

CAY 10566  (CAS 944808-88-2)

CAY 10566 is rated 5.0 out of 5 by 1.
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Synonym: 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine
Application: Buy CAS# 944808-88-2, a potent and selective inhibitor of SCD1
CAS Number: 944808-88-2
Purity: ≥98%
Molecular Weight: 389.81
Molecular Formula: C18H17ClFN5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
CAY 10566 sc-205109 1 mg $108.00
CAY 10566 sc-205109A 5 mg $487.00

3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine is a potent and selective inhibitor of SCD1; inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells.


References

1 Cohen, P., Miyazaki, M., Socci, N.D., et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297 240-243 (2002). 2 Dobrzyn, P., Sampath, H., Dobrzyn, A., et al. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am J Physiol Endocrinol Metab 294, E357-E364 (2008). 3 Miyazaki, M., Flowers, M.T., Sampath, H., et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metabolism 6 484-496 (2007). 4 Liu, G., Lynch, J.K., Freeman, J., et al. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. J Med Chem 50 3086-3100 (2007).

Physical State :
Solid
Solubility :
Soluble in 1:5 DMF:PBS (pH 7.2) (~0.15 mg/mL), ethanol (~0.15 mg/mL), DMSO (~10 mg/mL), and DMF (~10 mg/mL).
Storage :
Store at -20° C
IC50 :
SCD1 : IC50 = 4.5 nM (mouse); SCD1 : IC50 = 26 nM (human); the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs: IC50 = 7.9 nM (Hep-G2 cells); the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs: IC50 = 6.8 nM (Hep-G2 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16732433
SMILES :
CC1=NN=C(O1)C2=NN=C(C=C2)N3CCC(CC3)OC4=C(C=CC(=C4)F)Cl

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Certificate of Analysis

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Rated 5 out of 5 by from Mohammadzadeh F; et al Mohammadzadeh F; et al. (PubMed ID: 25013434) determined that CAY 10566, a Stearoyl-CoA desaturase 1 (SCD1) inhibitor, increased the amount of saturated fatty acids in breast tissue and overall tumor growth in breast cancer tissue samples. - SCBT Publication Review
Date published: 2015-06-09
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