Ebastine Ebastine is a non-sedating histamine H1 receptor antagonist that inhibits T cell migration as well and may find a use in the treatment of Th2-type autoimmune diseases.

Ebastine  (CAS 90729-43-4)

Ebastine is rated 5.0 out of 5 by 1.
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Application: An antagonist of the histamine H1-receptor
CAS Number: 90729-43-4
Purity: ≥98%
Molecular Weight: 469.66
Molecular Formula: C32H39NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Ebastine sc-205663 1 g $104.00
Ebastine sc-205663A 5 g $420.00

Ebastine is a non-sedating histamine H1 receptor antagonist that inhibits T cell migration as well and may find a use in the treatment of Th2-type autoimmune diseases.


References

1. Roberts, D.J. 1996. Drugs. 52: 8-14. PMID: 8828021
2. Nori, M., et al. 2003. Clin. Exp. Allergy. 33: 1544-1554. PMID: 14616867

Physical State :
Solid
Solubility :
Soluble in methanol, chloroform, and DMSO (>10 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
84-87° C
Boiling Point :
~596.3° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Histamine H1 Receptor: IC50 = 28.3 nM (human); SR-1A: IC50 = 47 nM (human); D2DR: IC50 = 61 nM (human); SR-2A: IC50 = 90.4 nM (human); Dopamine transporter: IC50 = 98.7 nM (human)
Ki Data :
Histamine H1 Receptor: Ki= 3.29 nM (human); SR-2A: Ki= 25.8 nM (human); α2C-AR: Ki= 40.1 nM (human); D3DR: Ki= 41.3 nM (human); Dopamine transporter: Ki= 78.4 nM (human)
pK Values :
pKb: 8.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EL8140000
PubChem CID :
3191
Merck Index :
14: 3484
MDL Number :
MFCD00865661
SMILES :
CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Nori et al Nori et al. (PubMed ID 14616867) found that the H1 receptor antagonist, ebastine, inhibited Th2-type cytokine production and T cell migration. -SCBT Publication Review
Date published: 2015-06-05
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