Indirubin-3'-monoxime Indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK1, CDK5, and reversibly arrests asynchronous HBL-100 cells at G22.

Indirubin-3'-monoxime  (CAS 160807-49-8)

Indirubin-3'-monoxime is rated 5.0 out of 5 by 1.
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Synonym: Indirubin-3’-oxime 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Application: A potent inhibitor of GSK-3β, Cdk1, and Cdk5
CAS Number: 160807-49-8
Purity: ≥98%
Molecular Weight: 277.30
Molecular Formula: C16H11N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Indirubin-3'-monoxime sc-202660 1 mg $75.00
Indirubin-3'-monoxime sc-202660A 5 mg $309.00
Indirubin-3'-monoxime sc-202660B 50 mg $645.00

Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.


References

1. Leclerc, S., et al. 2001. J. Biol. Chem. 276: 251-260. PMID: 11013232

Physical State :
Solid
Solubility :
Soluble in DMSO (6 mg/ml), ethanol (4 mg/ml), DMF (~10 mg/ml), 1:5 DMSO:PBS (pH 7.2) (0.15 mg/ml), and methanol. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
247-249° C
Boiling Point :
645.5° C at 760 mmHg (Predicted)
Density :
1.5 g/cm3
Refractive Index :
n20D 1.77
IC50 :
GSK-3β: IC50 = 22 nM; Cdk1: IC50 = 180 nM; Cdk5: IC50 = 100 nM; CDK2/cyclin A: IC50 = ~500 nM; CDK4/cyclin D1: IC50 = 3.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5326739
MDL Number :
MFCD02683594
SMILES :
C1=CC=C2C(=C1)C(=C(N2)C3=C4C=CC=CC4=NC3=O)NO

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Certificate of Analysis

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Rated 5 out of 5 by from Lee JJ; et al Lee JJ; et al. (PubMed ID: 25451564) determined that Indirubin-3'-monoxime inhibited collagen-induced platelet aggregation by suppressing phospholipase C 2 (PLC 2) phosphorylation, in rat carotid artery injury model. -SCBT Publication Review
Date published: 2015-01-09
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