Scoparone A compound found in the herb, Yin Chin, that can up-regulate the expression and activate the constitutive androstane receptor (CAR) found in the liver.

Scoparone  (CAS 120-08-1)

Scoparone is rated 5.0 out of 5 by 1.
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Synonym: 6,7-Dimethylesculetin, 6,7-Dimethoxycoumarin
Application: An agent that can up-regulate the expression and activate CAR
CAS Number: 120-08-1
Purity: ≥98%
Molecular Weight: 206.20
Molecular Formula: C11H10O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Scoparone sc-202806 25 mg $105.00

Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin (sc-202499) by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII© in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.


References

1. Baader, M., et al. 2002. J. Biol. Chem. 277: 15647-15653. PMID: 11867618
2. Lee, Y.M., et al. 2003. J. Biomed. Sci. 10: 518-525. PMID: 12928592
3. Huang, W., et al. 2004. J. Clin. Invest. 113: 137-143. PMID: 14702117
4. Lazar, M.A., et al. 2004. J. Clin. Invest. 113: 23-25. PMID: 14702104
5. Yang, Y.J., et al. 2008. Neurosci. Lett. 440: 14-18. PMID: 18547723
6. Yang, Y.J., et al. 2009. J. Neurosci. Res. 87: 1929-1937. PMID: 19185027
7. Yang, Y.J., et al. 2010. Fitoterapia. 81: 497-502. PMID: 20080157

Physical State :
Solid
Solubility :
Soluble in DMSO (15 mg/ml), and water (partly miscible).
Storage :
Store at 4° C
Melting Point :
143-145° C (lit.)
Boiling Point :
327.2-411.2° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
fMLP/cytochalasin B-induced superoxide radical anion generation : IC50 = 41.4 µM (human neutrophils )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GN6550000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
8417
Merck Index :
14: 8404
MDL Number :
MFCD00006871
EC Number :
204-369-0
SMILES :
COC1=C(C=C2C(=C1)C=CC(=O)O2)OC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Yang et al Yang et al. (PubMed ID 20080157) found that scoparone increases dopamine release by synapsin I phosphorylation through activation of PKA and CaMK II, which are mediated by cyclic AMP levels and calcium influx. -SCBT Publication Review
Date published: 2015-06-04
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