TEMPOL TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, with the ability to permeate the membrane, and restore the effects of TNF-α.

TEMPOL  (CAS 2226-96-2)

TEMPOL is rated 5.0 out of 5 by 1.
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| See 10 Citations
Synonym: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Application: A superoxide dismutase mimetic that restores the effects of TNF-α
CAS Number: 2226-96-2
Purity: ≥99%
Molecular Weight: 172.25
Molecular Formula: C9H18NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
TEMPOL sc-200825 1 g $26.00

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


References

1. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
2. Xu, H., et al. 2004. Hypertension. 43: 329-334. PMID: 14707156
3. Khattab, M.M., 2006. Eur. J. Pharmacol. 548: 167-173. PMID: 16973155
4. Lipman, T., et al. 2006. Eur. J. Pharmacol. 549: 50-57. PMID: 16989807
5. Mariappan, N., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H2726-H2737. PMID: 17675574
6. Pires, P.W., et al. 2010. Microvasc Res. PMID: 20600163

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (1670 g/l) at 20° C, ethanol (100 mM), methanol, and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
69-71° C (lit.)
Boiling Point :
269° C
Density :
1.19 g/cm3
IC50 :
Plasmodium falciparum K1: IC50 = 19 µg/ml; Plasmodium falciparum NF54: IC50 = 27 µg/ml
pK Values :
pKb: 5.15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
TN8991000
PubChem CID :
137994
Merck Index :
14: 9141
MDL Number :
MFCD00006478
EC Number :
218-760-9
Beilstein Registry :
1422990
SMILES :
CC1(CC(CC(N1[O])(C)C)O)C

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Certificate of Analysis

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TEMPOL Product Citations

See how others have used TEMPOL. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 25793256
Patki, G. et al. 2015. Tempol treatment reduces anxiety-like behaviors induced by multiple anxiogenic drugs in rats. PLoS ONE. 10: e0117498.

PMID: # 26000607
Zhang, M. et al. 2015. The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PloS one. 10: e0127386.

PMID: # 24879153
Tiwari, M. et al. 2014. A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy. 10: 1054-70.

PMID: # 24144633
Su, Y. et al. 2013. Uncoupling of eNOS contributes to redox-sensitive leukocyte recruitment and microvascular leakage elicited by methylglyoxal. Biochem. Pharmacol.. 86: 1762-74.

PMID: # 23747723
Sun, B. et al. 2013. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem. Biophys. Res. Commun.. 436: 591-4.

PMID: # 24167244
Farrow, MA. et al. 2013. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc. Natl. Acad. Sci. U.S.A.. 110: 18674-9.

PMID: # 24086737
Brozovic, A. et al. 2013. Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells. PloS one. 8: e76397.

PMID: # 23380026
Kim, BS. et al. 2013. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free Radic. Biol. Med.. 60: 336-346.

PMID: # 24050620
Su, Y. et al. 2013. Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells. Cardiovasc Diabetol. 12: 134.

PMID: # 17675574
Mariappan, N. et al. 2007. TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. Am. J. Physiol. Heart Circ. Physiol.. 293: H2726-H2737.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Worked well in our experiments Worked well in our experiments, happy with purchase.
Date published: 2015-06-10
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