Terbinafine hydrochloride Terbinafine·HCl is a potent squalene epoxidase inhibitor and, as a result, a suppressor of ergosterol biosynthesis. Also reported as a free radical scavenger as well as an anti-angiogenic agent.

Terbinafine hydrochloride  (CAS 78628-80-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 46ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
Application: A squalene monooxygenase inhibitor
CAS Number: 78628-80-5
Purity: 99%
Molecular Weight: 327.9
Molecular Formula: C21H25N•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Terbinafine hydrochloride sc-200751 100 mg $70.00
Terbinafine hydrochloride sc-200751A 1 g $135.00

Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Research has shown that Terbinafine also reduces the ability of fungal pathogens to generate reactive oxygen species, therefore it is noted as a free radical scavenger in vitro and could potentially contain anti-inflammatory activity in vivo. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed. Assays further demonstrated that Terbinafine also contains anti-angiogenic effects in chick embryo chorioallantoic membranes. We provide this product in the hydrochloride form.


References

1. Ryder, N.S. 1992. Br. J. Dermatol. 126: 2-7. PMID: 1543672
2. Favre, B., et al. 1997. Arch. Biochem. Biophys. 340: 265-269. PMID: 9143330
3. Sander, C.S., et al. 2002. Mycoses. 45: 152-155. PMID: 12100530
4. Ho, P.Y., et al. 2004. Int. J. Cancer. 111: 51-59. PMID: 15185342
5. Motavaze, K., et al. 2008. Iran. Biomed. J. 12: 55-58. PMID: 18392096

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, ethanol (~30 mg/ml), methylene chloride, DMSO (~10 mg/ml), DMF (~10 mg/ml), and 1:2 solution of ethanol:PBS (pH 7.2) (0.3 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
214° C
Boiling Point :
417.9° C at 760 mmHg
IC50 :
ergosterol synthesis at the stage of squalene epoxidation: IC50 = 30 nM (C. albicans)
Ki Data :
squalene epoxidase: Ki= 30 nM (Candida)
pK Values :
pKb: 6.92
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QJ8600100
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
5282481
Merck Index :
14: 9156
MDL Number :
MFCD00145430
EC Number :
245-385-8
SMILES :
Cl.CN(CC=CC#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 129ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 36ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2016 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.